Classical and advanced chemical sciences
One-pot three-component synthesis of 3,4-dihydro-3,3-dimethyl-9-phenylacridin-1 (2H,9H,10H)-one derivatives has been described by the cyclocondensation of aromatic aldehydes, aromatic amines and dimedone in the presence of 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) in ethanol at reflux condition. Besides buffering agent, HEPES as an organocatalyst has been used for the first time in multicomponent organic transformation and succeeded along with various merits of green chemistry practices. The reaction is mechanized by zwitterionic interactions between organocatalyst and reactants to form targeted molecules.
Keywords: HEPES buffer; phenylacridin-1-ones; organocatalyst
Synthesis, characterization, antioxidant and antimicrobial activities of novel pyrazolines and phenylpyrazoline containing substituted pyridine and piperazine benzoisothiazole moieties have been reported. When these synthesized compounds were exposed for antioxidant screening, some among them exhibited prominent DPPH radical scavenging activity and superoxide radical (SOR) scavenging activity where ascorbic acid used as standard. During the antimicrobial screening compounds, some derivatives were found to be very active against Cryptococcus neoformans, which was supported on the basis of higher free binding energies with methionyl-tRNA synthetase.
Keywords: Pyrazolines; antioxidant; antimicrobial; molecular docking
A series of N-alkoxy-N’,N’,N-trimethylhydrazinium chlorides by interaction of N-alkoxy-N-chlorocarbamates with trimethylamine could be prepared
Keywords: N-Alkoxy-N-chlorocarbamates, N-alkoxyhydrazines, N-alkoxy-N’,N’,N’-trimethylhydrazinium chlorides, synthesis, O-N-N geminal systems, nucleophilic substitution at nitrogen
Materials and environmental chemistry
The main goals of the research are to study the drug delivery nanoparticle, G4 PAMAM (polyamidoamine) dendrimer, using spectroscopic and thermodynamic methods and, based on the unique properties of G4 PAMAM dendrimer, create new, stable nano-sized (∼5 nm) metalorganic nanocomplexes with silver atoms, which have a strong absorption in visible area and it can be used as a photo thermotherapeutic agent for the treatment of cancer cells.
Keywords: G4 PAMAM (polyamidoamine) dendrimers, DNA, silver ions, nanomedicine; phototherapy
In this study, the preparation of quinoxaline derivatives using α-diketones, 1,2-phenylene diamines in the presence of H2SO4/SiO2 catalyst in ethylene glycol and at room temperature is reported. The advantages of this method are high yields of the products, utilizing of reusable catalyst, easy separation and mild reaction conditions. Also, reusability of the catalyst was investigated and found that catalytic activity of the catalyst did not decreased after 4th times.
Keywords: Quinoxalines, sulfuric acid/SiO2 catalyst, diketones, phenylene diamine, green synthesis
Chemical and biological aspects of life
The properties of 3 and 6 mol % copper-containing bioactive glasses have been evaluated. The structure of the doped glass has been studied by X-ray diffraction (XRD), X-ray photoelectron survey (XPS), high-resolution scans and NMR spectroscopy. The results indicated that copper acts as a network modifier in the glass composition and copper-containing glasses show a less connected microstructure. Differential Thermal Analysis (DTA) showed that the copper addition in the glass lowers the glass transition temperature. Antibacterial studies showed that doping with copper enhances the antibacterial effect of the bioglass
Keywords: Biomedical glasses, copper, structure, XPS, antibacterial